Sunday, September 25, 2016

Water Channel Protein May Help to Diagnose Malignant Mesothelioma

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http://mesotheliomaresearchnews.com/wp-content/uploads/2016/07/shutterstock_291666776-1024x683.jpgThe researchers found that a protein called Aquaporin 1 (AQP1), is a useful biomarker in patients with malignant mesothelioma. 
 The study "Usefulness of Aquaporin 1 as a prognostic marker in a prospective cohort of mesothelioma," was published in the International Journal of Molecular Sciences.

The researchers assessed whether AQP1 could act as an independent prognostic factor in two separate cohorts of malignant mesothelioma is patients.AQP1 a widely expressed water channel allowing water to pass easily through the plasma membranes of red blood cells and tubules proximal renal.

 In addition to their role in the transport of water, aquaporin proteins also play a role in cell proliferation and pain perception.
 Expressed in tumor cells and, aquaporins have been used in the prognosis of cancer, and they have recently been studied as potential targets for the treatment of cancer.

The team found that some malignant mesothelioma had increased expression of AQP1 and assessed its value as a prognostic marker.

 Tissue samples from 104 consecutive cases of malignant mesothelioma were extracted and evaluated for expression of AQP1.
 Two pathologists then analyzed the expression of the protein in the tissue, and results were correlated with the full clinical information and monitoring.
 In total, samples from 91 cases were included in this analysis.

The researchers observed that AQP1 was maintained as a significant indicator of prognosis, but only in univariate analysis (ie when only one variable is considered).

 The significant prognostic value of AQP1 was reduced in the multivariate analysis (with several variables). 
 These results, the authors noted, were consistent with previous results showing that AQP1 varies between different histological subtypes of MM.

The researchers concluded that AQP1 is a useful prognostic marker, with higher levels of AQP1 showing a better prognosis in malignant mesothelioma.

 AQP1, they suggest, is useful as a tool and can be easily integrated into existing diagnostic tests using tissue staining and analyzed by pathologists.
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